Organ-Hugging ‘Skinny Fat’ Puts Health At Risk In People With Normal BMI

A standard body fat test may not reveal the true scope of your overall health. (© Dmytro Panchenko – stock.adobe.com)
In A Nutshell
- What the study found: In 33,000 adults from Canada and the UK, more visceral fat (fat around internal organs) tracked with thicker carotid artery walls, even after accounting for age, blood pressure, cholesterol, diabetes, and smoking.
- Why it matters: BMI and the mirror can mislead. Two people with the same BMI can carry fat in different places; the person with more visceral fat may have higher cardiovascular risk signals.
- How it might work: Visceral fat acts like active tissue. It may release inflammatory signals, affect insulin and cholesterol handling, and strain the liver, which together can stress blood vessels.
- What to do next: This study shows association, not cause and effect. Ask your clinician about simple checks like waist-to-hip ratio and routine metabolic labs, and discuss habits that improve body composition and fitness.
HAMILTON, Ontario — Maria steps on the scale each morning and sees the same number she’s maintained for years. Her doctor says her weight is fine. Her friends compliment her figure. But deep inside her body, fat is quietly wrapping around her organs like a dangerous blanket, setting the stage for heart disease.
Maria represents millions of people caught in the “skinny fat” trap: looking healthy on the outside while carrying hidden fat that threatens their arteries. New research involving over 33,000 people reveals that this invisible fat around internal organs damages blood vessels just as much as being visibly overweight.
Scientists from Canada and Britain scanned thousands of adults to see exactly where fat sits in their bodies and how it affects their arteries. What they discovered challenges everything we think we know about who’s at risk for heart disease.
The study focused on typical middle-aged adults, many already carrying extra weight. But the findings have serious implications for people who maintain normal weight on the scale while accumulating dangerous fat around their organs — fat that regular check-ups can’t detect.
People with more of this hidden fat, called visceral fat, developed thicker artery walls regardless of their overall weight or other risk factors like blood pressure and cholesterol. The Canadian study found clear connections between internal fat and artery damage. The British study confirmed these results using different measurement techniques.
When researchers crunched the numbers, they discovered the internal fat effect was significant. People with higher levels faced 19-32% higher heart disease risk. Other studies show that even small improvements in artery health can cut heart attack and stroke risk by 16%.

When BMI Measurements Fall Short
This research adds to evidence that where fat accumulates matters more than total weight for health outcomes. Two adults with identical BMI scores can carry vastly different amounts of dangerous internal fat, resulting in different cardiovascular risk profiles despite similar appearances.
Consider two middle-aged individuals both with BMI scores of 25. Person A stores fat primarily under the skin, while Person B accumulates fat around internal organs. Despite identical weight classifications, Person B faces elevated cardiovascular risk that BMI measurements alone cannot capture.
Men carried notably more visceral fat than women in this study, averaging 82.8 milliliters compared to 60.8 milliliters, and also demonstrated higher rates of artery damage.
How Visceral Fat May Affect Arteries
Visceral fat operates differently from subcutaneous fat, with researchers proposing it functions like an active tissue that releases inflammatory substances directly into the bloodstream. These compounds may disrupt insulin function, modify cholesterol patterns, and potentially accelerate artery-damaging processes.
Scientists employed imaging methods to assess both fat distribution and artery condition. Participants underwent abdominal MRI scans to measure visceral fat volumes and liver fat content. Artery health was determined through carotid wall volume measurements in Canada and ultrasound-based thickness assessments in the UK.
Both studies generated consistent results despite different measurement approaches. Combined analysis showed a clear relationship: higher visceral fat levels corresponded with increased artery damage markers, independent of total body weight.
Why Standard Health Checks Overlook ‘Skinny Fat’
The research team from McMaster University and collaborating institutions emphasizes that standard weight measurements provide incomplete health pictures. Healthcare providers relying primarily on BMI calculations may overlook significant numbers of at-risk patients.
“Abdominal obesity has stronger associations with cardiometabolic risk than overall obesity assessed by BMI,” the study authors observed. This supports mounting medical evidence that fat distribution predicts health outcomes more accurately than total weight.
People with the “skinny fat” pattern often have visceral fat that cannot be assessed through standard measurements. Unlike obvious weight changes that prompt lifestyle adjustments, visceral fat can accumulate while individuals maintain confidence about their health status based on stable weights and normal BMI readings.
Why Visceral Fat Is So Dangerous
Scientists theorize that visceral fat accumulation may represent a storage overflow within the body. The authors note proposed theories suggesting that when subcutaneous fat cells reach capacity limits, excess energy might get redirected to organ-adjacent areas where it could cause more direct metabolic effects.
This overflow process may trigger inflammation as immune cells respond to expanding fat tissue. Inflammatory compounds could then circulate through the bloodstream, potentially contributing to artery changes via mechanisms including insulin resistance and altered cholesterol metabolism.
The liver faces particular vulnerability since it receives blood directly from visceral fat deposits. Fat accumulation in liver cells may impair the organ’s blood sugar regulation and cholesterol production, potentially creating cascading metabolic changes.
However, the research revealed an important distinction about liver fat: it showed associations with cardiovascular risk factors primarily when visceral fat was also elevated. When researchers analyzed liver fat independently while controlling for visceral fat levels, the associations with artery measurements became much weaker.

Moving Beyond Weight-Focused Health
Addressing patterns related to body composition requires approaches that differ from conventional weight management. Since total weight may remain in healthy ranges, the focus shifts to overall metabolic health and lifestyle factors that support healthy fat distribution.
The study did not test specific treatments, but in clinical practice, healthcare providers typically focus on overall fitness, diet quality, and metabolic risk factor management. Some research supports eating patterns that emphasize whole foods, regular physical activity including resistance training, and maintaining healthy sleep and stress patterns.
This study used a cross-sectional design, capturing associations at one time point rather than tracking changes over time. Because of this limitation, the research cannot establish that visceral fat directly causes artery damage, only that the two are associated.
For healthcare providers, these associations suggest cardiovascular risk assessment could benefit from considering body composition alongside traditional measurements. Simple clinical measures like waist-to-hip ratio might provide additional information beyond BMI alone.
The research points toward future health assessment that incorporates metabolic function and body composition rather than relying on weight categories alone. The key message remains that external appearance and weight stability don’t provide complete information about cardiovascular health, and that fat distribution warrants attention as part of an overall health assessment.
Paper Summary
Methodology
Researchers conducted a cross-sectional analysis using two large population studies. The Canadian Alliance for Healthy Hearts and Minds (CAHHM) study included 6,760 adults aged 35-69 from eight Canadian provinces, while the UK Biobank provided data from 26,547 participants aged 40-69. All participants underwent MRI scans to measure visceral fat volume and liver fat content. Artery health was assessed through carotid wall volume measurements via MRI in the Canadian study and carotid intima-media thickness through ultrasound in the UK study. Researchers used statistical models to control for traditional cardiovascular risk factors including age, smoking, blood pressure, cholesterol, and diabetes.
Results
Higher visceral fat levels were consistently associated with increased artery wall thickness in both studies. In the Canadian cohort, each standard deviation increase in visceral fat corresponded to 6.16 cubic millimeters more carotid wall volume, while the UK study showed 0.016 millimeters greater artery thickness per standard deviation of visceral fat. These associations persisted after adjusting for conventional cardiovascular risk factors. Liver fat showed weaker associations with artery damage compared to visceral fat. Men typically had higher visceral fat levels and more pronounced artery changes than women.
Limitations
The study’s cross-sectional design prevents establishing causation between fat accumulation and artery damage over time. Researchers could not exclude participants with excessive alcohol consumption due to questionnaire limitations. The pooled analysis combined different measurement techniques (MRI versus ultrasound) for assessing artery health, which may limit direct comparisons. Additionally, the precision limitations of measuring artery thickness in clinical practice mean extrapolating these findings to predict individual cardiovascular events requires caution.
Funding and Disclosures
CAHHM was funded by the Canadian Partnership Against Cancer, Heart and Stroke Foundation of Canada, and Canadian Institutes of Health Research, with additional contributions from various institutions. The UK Biobank receives support from multiple government and charitable organizations. Several authors reported potential conflicts of interest, including consulting relationships with pharmaceutical companies and ownership stakes in medical imaging software companies. One author holds shares in Circle Cardiovascular Imaging, which developed software used in the analysis.
Publication Information
De Souza, Russell J., Pigeyre, Marie et al. “Visceral adipose tissue and hepatic fat as determinants of carotid atherosclerosis.” doi:10.1038/s43856-025-01123-y. The study was published October 17, 2025 in Communications Medicine, a Nature Portfolio journal, and received ethical approval from appropriate research ethics boards in both Canada and the United Kingdom.
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